复发性妊娠丢失（RPL）是一种多因素病症，其特征为连续发生两次或两次以上的妊娠丢失，影响约1-2%的备孕夫妇。尽管生殖医学已取得诸多进展，仍有大量RPL病例病因不明（URPL），这使其成为 诊断 与治疗领域的重大挑战。

二氢乳清酸脱氢酶（DHODH）已被证实是程序性细胞死亡的关键调控因子，但其在巨自噬/自噬中的作用尚不明确。黄病毒科病毒对全球公共卫生构成重大威胁，其复制过程与自噬密切相关。

高尔基体是真核细胞内重要的膜系统枢纽与分泌工厂，被称为“蛋白质分拣站”，同时也是动态的信号整合与代谢调控中心。研究团队发现，NDV感染引发高尔基体应激，导致其损伤解体，并最终通过选择性自噬途径被降解。伴随这一过程，高尔基体关键驻留蛋白ARF1也明显减少。ARF1作为小G蛋白家族成员，是维持细胞器间通讯、脂肪酸代谢和氧化还原稳态的重要因子。其下调可导致细胞内活性氧积累和脂质过氧化增强，进而诱导以铁依 ...

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