Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle, ...

The metabolism of uric acid is an essential facet of purine degradation, with significant implications for human health. In most mammals, uricase converts uric acid into allantoin, which is readily ...

This image illustrates the chemical structure of a purine molecule, highlighting the numbering of the carbon and nitrogen atoms. The purine structure consists of a pyrimidine ring (positions 1 to 6) ...

Parkinson's disease (PD), the second most common neurodegenerative disorder globally, has long baffled scientists with its progressive nature and debilitating effects on motor function. A recent study ...

Cell metabolism is often thought of as the process of breaking down sugars to create energy, but the process also involves all the biosynthetic reactions necessary to sustain life. One of these ...

Gut microbiota capable of metabolizing uric acid and purines may play a key role in reducing gout diagnoses, and although the findings from new retrospective and prospective studies suggest key roles ...

While modern life includes many conveniences, humans are still incessantly exposed to a variety of metabolic stresses we have ...

Uric acid is a natural waste product produced when the body breaks down a compound called purines, which is found in foods and beverages. Under normal circumstances, uric acid is excreted in urine.