LpxC inhibitors target a zinc-dependent deacetylase that catalyses the first committed step in lipid A biosynthesis, an essential process for the viability of Gram-negative bacteria. As lipid A forms ...

The Tol-Pal complex maintains bacterial outer membrane (OM) stability by regulating lipid homeostasis. (Left) In Gram-negative bacteria, the OM acts as a protective barrier, blocking entry of harmful ...

Trial comes up negative, but shorter hospital stays observed in carbapenem-resistant cases ...

The proportion of extensively drug-resistant (XDR) Shigella isolates in the United States increased from 2011–2015 to 2023, according to research published in the April 9 issue of the U.S. Centers for ...

Scientists from Cornell University, University of California, San Francisco (UCSF), and elsewhere have found that a surplus of membrane proteins may help bacteria survive antibiotic exposure. These ...

• Require X (hemin) and/or V (nicotinamide adenine dinucleotide) factors for growth • Responsible for 0.5–1% of all cases of IE • Haemophilus aphrophilus is the most common species responsible for IE ...

Recent studies suggest that animals and people alike have close and complex relationships with the bacteria around and within them. The human gut microbiome, for instance, has been associated with ...

A new study published in the Journal of the American Medical Association revealed that rapid blood culture antimicrobial ...

Rapid antimicrobial susceptibility testing for gram-negative blood infections shows no improvement in clinical outcomes ...