Scientists at Duke University School of Medicine in Durham, North Carolina, have developed a small-molecule inhibitor of the cellular stress-protective transcription factor, heat shock factor 1 (HSF1) ...

Radiation Research, Vol. 176, No. 1 (July 2011), pp. 17-24 (8 pages) HSF1 is a transcription factor that plays a key role in the response to heat stress and was previously shown by us to also be ...

The study, published in the journal Cell, was conducted at the Whitehead Institute of Biomedical Research. Long associated with enabling the proliferation of cancer cells, the ancient cellular ...

Although rare compared to adult liver cancers, hepatoblastoma is the most common pediatric liver malignancy, and its incidence is increasing. In this novel study appearing in The American Journal of ...

AUGUSTA, Ga. – Altering the body's metabolism could be an effective treatment for deadly liver cancer, researchers report. The finding that inhibiting heat shock transcription factor 1, or HSF1, ...

Heat shock factors (HSFs) are the main transcriptional regulators of the evolutionarily conserved heat shock response. Beyond cell stress, several studies have demonstrated that HSFs also contribute ...

For the first time, researchers have discovered a link between a pathway that activates a protein called heat shock transcription factor 1 (HSF1) and leukemia. Blocking even just a single gene in this ...

Scientists pinpoint an unusual culprit in cancer: a family of genes that respond to temperature changes in the body. Disruptions in circadian rhythm -- the ways that our bodies change in response to ...