Colorectal carcinoma (CRC) represents one of the most frequent malignancies worldwide, with a correspondingly high death toll. Moreover, the identification of predictive markers for patient ...
For 50 years the dosing of anticancer drugs has been empirical—small phase I trials predict a tolerable dose, and subsequent studies refine the accuracy of that prediction. Because of population ...
A phase I dose escalation study of irinotecan (CPT-11), oxaliplatin (Oxal), and capecitabine (Cap) within three UGT1A1 TA promoter cohorts (6/6, 6/7, and 7/7) ...
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