Transforming growth factor (TGF)-β regulates the expression of matrix metalloproteinases (MMPs) and components of the extracellular matrix, thereby profoundly affecting the microenvironment of cells ...

Cleveland, OH - Researchers are reporting that a deletion mutation in a gene called MEF2A, encoding for one of a family of transcription factors, causes an inherited disorder identical to CAD and ...

Coronary artery disease (CAD) is one of the major killers in Western societies. Recently, mutations in a gene called MEF2A on chromosome 15 were reported to be causative of premature CAD. The authors ...

Move over CREST and CREB; there are other calcium-activated factors that control the synaptic complement. The February 17 issue of Science draws attention to MEF2 transcription factors, while a recent ...

In data published on 28 November, researchers from the Cleveland Clinic showed that a mutation of the gene MEF2A discovered in an analysis of the genetic makeup of 21 members of an Iowa family – has a ...