Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme, which converts GTP to the second messenger cGMP in response to signalling from gaseous ligands, particularly nitric oxide (NO).

2 Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA 3 Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, Kentucky, USA Correspondence to ...

Small vessel disease is a disorder of cerebral microvessels that causes white matter hyperintensities and several other common abnormalities (eg, recent small subcortical infarcts and lacunes) seen on ...

The “2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage” replaces the 2012 “Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage.” The 2023 guideline ...

fDepartments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA ...

Cluster headache is a primary headache syndrome that is characterized by excruciatingly severe, strictly unilateral attacks of orbital, supraorbital or temporal pain, which last 15–180 min and are ...

Nitric oxide (NO) is a small free radical generated by a family of enzymes, the nitric oxide synthases (NOSs). Following injury to a tendon, NO is induced by all three isoforms of NOS and NOS activity ...