本研究针对Epothilone B工业化生产瓶颈，通过烟曲霉菌(Aspergillus fumigatus)替代传统来源Sorangium cellulosum，解析其化学结构及抗癌 ...

挥发性麻醉剂能够使人类暂时失去行动能力和意识，它们对非神经生物（包括植物和单细胞生物）的运动能力也有类似的可逆影响。其具体作用机制尚不清楚，但由于不同组织和细胞类型之间的复杂相互作用，在哺乳动物中进行研究较为困难。本文利用免费软件 ...

The microtubule-stabilizing drug epothilone B (epoB) has shown potential value in the treatment of spinal cord injury (SCI) through diverse mechanisms. However, it remains elusive why a limited ...

Damage to the spinal cord rarely heals because the injured nerve cells fail to regenerate. The regrowth of their long nerve fibers is hindered by scar tissue and molecular processes inside the nerves.

The epothilone B analogs are non-taxane tubulin stabilizing compounds that are active in taxane-resistant and -sensitive preclinical models. BMS-247550 is a semi-synthetic epothilone B analog that has ...

Phase II Clinical Trial of Ixabepilone (BMS-247550), an Epothilone B Analog, As First-Line Therapy in Patients With Metastatic Breast Cancer Previously Treated With Anthracycline Chemotherapy Patients ...

Co presented updated data from a Phase 1 clinical trial showing that KOS-1584/R1645, an epothilone under co-development with Roche, demonstrated antitumor activity and tolerability in patients with ...

Company will evaluate 11 preclinical candidates with nab technology. Abraxis BioScience and The Scripps Research Institute (TSRI) are collaborating to develop and commercialize an epothilone ...

Roche and Kosan Biosciences Incorporated they have signed a collaboration agreement to globally co-develop and co-commercialize Kosan''s new generation anti-cancer drug candidate, KOS-862 (Epothilone ...

A compound that previously progressed to Phase II clinical trials for cancer treatment slows neurological damage and improves brain function in an animal model of Alzheimer's disease, according to a ...

CHESTNUT HILL, MA (11/2/11) – Research carried out at Boston College, in collaboration with scientists at MIT and the University of Oxford, has led to the development of an efficient and highly ...